-B.A. Ewha Womans University
-M.S., Louisiana State University
-Ph.D., Louisiana State University
Office: N219 Oliphant
Phone: (918) 631-2310
My research goal is to probe the biological mechanisms
underlying aging and calorie restriction (CR). I am
attempting to employ novel molecular biological approaches (gene expression arrays) that seem likely to undercover
altered pattern of gene expression in mice and rats under CR. Finding
differences in gene expression between ad libitum fed and CR animals may give clues to the question, “how does
The answer to this question is my ultimate
I have been awarded two grants, a National
Institute of Health grant (1 KO1 AG00746) to study genes to acutely responsive to CR and a National Institute of
Health grant (SG 5 PO1 AG14674) to study altered gene expression in transgenic mice which mimic the CR traits.
- Gokhale, D.V., E.S. Han,
V.R. Srinivasan, and D.N. Doebagkar 1984 Transfer
of DNA coding for cellulase from Cellulomonas species to Bacillus subtilis by protoplost fusion. Biotechnology Letters 6(10):627-632.
E.S., W.H. McGaughey, D.E. Johnson,
P. Dunn, and A.I. Aronson 1988 Characterization of Bacillus thuringiensis isolates effective on resistant indian
A.T. and J.A. Hoch (eds.), Genetics and Biotechnology of Bacilli, Vol. 2, Academic Press, San Diego, pp. 233-238.
- Sakaguchi, A.Y., P.A. Lalley, G. Ghosh-Choudhury,
L. Martinez, E.S. Han,
A.M. Killary, S.L. Naylor, and L.-M. Wang 1989 Mouse
melanoma growth stimulatory activity gene (mgsa) is polymorphic and syntenic with the W. Patch, rumpwhite, and
recessive spotting loci on chromosome 5. Genomic
- Aronson, A.I., E.S. Han,
W. McGaughey, and D. Johnson 1991 The solubility
of inclusion proteins from Bacillus thuringiensis is dependent upon protoxin composition and is a factor in toxicity
Applied Environmental Microbiology 57(4):981-986.
E.S., M.P. Moyer, S. Naylor, and
A.Y. Sakaguchi 1991 Mutation in the TP53 gene in colorectal carcinoma detected by polymerase chain reaction. Genes, Chromosomes and Cancer 3:313-317.
- Sakaguchi, A.Y., V.L. Sylvia, L. Martinez, E.A.
Smith, E.S. Han,
P.A. Lalley, T.B. Shows, and G.G.Choudhury 1992 Assignment
of tyrosine-specific T-cell phosphatase to conserved syntenic groups on human chromsome 18 and mouse chromosome
E.S., N. Levin, N. Bengani, J. Roberts,
Y. Suh, K. Karelus, and J.F. Nelson 1995 Hyperadreno-corticism
and food restriction-induced life-extension in the rat: Evidence
for divergent regulation of pituitary proopiomelanocortin RNA and adrenocorticotropic hormone biosynthesis. J. Gerontol. Biol. Sci. 50A(5):B288-B294.
E.S., D.H. Lu, and J.F. Nelson 1998 Food restriction differentially affects on messenger RNAs
encoding the major anterior pituitary tropic hormones. J. Gerontol. Biol. Sci. 53A(5):B322-B329.
E.S., T.R. Evans, and J.F. Nelson
Adrenocortical responsiveness to adrenocorticotropic
hormone is enhanced in chronically food restricted rats. J. Nutr. 128:1415-1420.
E.S., S.G. Hilsenbeck, A. Richardson,
and J.F. Nelson 2000 cDNA
expressin arrays reveal incomplete reversial of age-related changes in gene expression by calorie restriction.
Mech. Age. Dev. 115(3):157-174.
E-S., H. Van Remmen, M. Steinhelper,
M.A. Pahlavani, J.R. Strong, and A. Richardson 2001 Effect
of age on gene expression. In Handbook
of Biology of Aging (Masoro, E.A., J. Campisi, and S. Austad, eds), Academic Press, San Diego, pp. 140-178.
E.S., and S.G. Hilsenbeck 2001 Array-based gene expression profiling to studying aging.
Mech. Age. Dev. 122(10): 999-1018.
E.S., T.R. Evans, J.H. Shu, S. Lee,
and J.F. Nelson 2001 Food
restriction enhances endogenous and corticotropin-induced plasma elevations of free but not total corticosterone
throughout life in rats. J. Gerontol. Biol. Sci. 56A(9):B391-B397.
E.S., T.R. Evans, S. Lee, and J.F.
Food restriction differentially affects
rat pituitary hormone mRNAs throughout the adult life span of male F344 rats. J. Nutr. 131:1687-1693.
- ,Han, E. S., Y. Wu, R. McCarter, J.F. Nelson, A. Richardson, and S.G. Hilsenbeck 2004 Reproducibility,
sources of variability, pooling, and sample size: Important considerations for the design of high density oligonucleotide
array experiments. J. Gerontol. Biol. Sci. 59A (4); 306-315.
- Fu, C., L. Xi, Y. Wu, R. McCarter, A. Richardson,
M. Hickey, and E.S. Han 2004 Hepatic genes altered in expression by food restriction
are not influenced by the low plasma glucose level in young male GLUT4 transgenic mice. J. Nutr. 134: 2965-2974.
- Cook, P., C. Fu, M. Hickey, E.S. Han, and K. S. Miller 2004 SAS programs for real-time QRT-PCR experiments having multiple
independent samples. Biotechniques. 37(6): 990-995.
- Han, E.S and M. Hickey 2005 Microarray evaluation of dietary restriction. J. Nutr. 135: 1343-1346.
- Fu, C., L. Xi, R. McCarter, M. Hickey, and E.S. Han 2006 Early hypothalamic response to age-dependent gene expression by calorie restriction.
Neurobiol. of Aging. 27(9): 1315-1325.
- Fu, C., M. Hickey, M. Morrison, R. McCarter, E.S. Han 2006 Tissue specific and non-specific changes in gene expression by aging and by early
stage CR. Mech. Age. Dev. 127(12): 905-916.
Research Students and Projects:
- Anti-aging mechanisms of
- Identifying altered gene
expression by oxidative stress
- Biol 1003-Genetics and Human
- Biol 4263, 6263-Selected
Topics in Molecular Genetics
- Biol 4344, 6444-Advanced
- Biol 4340L, 6440L- Advanced
Molecular Biology Laboratory
- Biol 7263-Seminar in Cell/Molecular
Microarray Core Facility (http://www.utulsa.edu/microarray/)